UJR 2019, VOL. XXVII, PUB. 1
2019, VOL. XXVII, PUB. 1, PAGE 5
V. VORONKO1, R. DRONOV1, B. SHRAMENKO1, I. BELOZIOROV2, I. GIRKA2
1 National Science Center Kharkov Institute of Physics and Technology
2 V. N. Karazin Kharkiv National University
POSSIBILITIES OF OBTAINING RADIOPHARMACEUTICALS «GLUCOSE, 11C» AND «ETHANOL, 11C» FOR PET TOMOGRAPHY ON ACCELERATORS OF NSC KHIPT
Ultra-short-lived isotopes 18F and 11C for positron emission tomography (PET) are usually obtained using a
cyclotron proton accelerator or by photonuclear method using linear electron accelerator or microtron. In the
NSC KhIPT, the possibility of obtaining new radiopharmaceuticals labeled with the 11C isotope, ready for use for
PET diagnostics and treatment, has been successfully implemented in practice. The prerequisite for the effective
operation of the PET center is the placement of the accelerator in close proximity to the PET tomograph. Such
a condition is satisfied in the proposed PET center version. The PET tomograph and accelerators (cyclotron,
microtron) are suggested to be located in the existing neighboring buildings of the KhNU. Transportation of
the pharmaceuticals labeled with isotopes 11C and 18F is planned to be carried out by means of pneumatic mail.
Implementation of the Proposal will allow establishing not simply a typical PET diagnostic center in the Kharkiv
region. A unique cancer center will be established based on the new radiopharmaceuticals «Ethanol, 11C». These
radiopharmaceuticals are already obtained by the researchers of the NSC KhIPT of the National Academy of
Sciences of Ukraine after the development of the method for cancer treatment with normal ethanol in the United
States.
Keywords: positron emission tomography, cyclotron, microtron, radiopharmaceutical, «Glucose, 11C», «Ethanol, 11C»,
cancer treatment.
2019, VOL. XXVII, PUB. 1, PAGE 10
N. BELOZOR, N. MITRYAEVA, V. STARENKY, L. GREBENIK
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
THE IMPACT OF THE COMBINED ACTIONS OF CONFORMAL RADIATION THERAPY AND COX-2 INHIBITOR ON CONTENTS OF VEGF, COX-2, PGE-2 IN SERUM OF PATIENTS WITH NON-SMALL CELL LUNG CANCER
The purpose of the work. To study of influence of combined actions of conformal radiation therapy and COX-2
inhibitor on treatment effectiveness and content of VEGF, COX-2 and PGE 2 in serum of patients with non-small
cell lung cancer.
Materials and methods. To assess The results.of the study 28 NSCLC aged 54 to 73 years were divided into
two subgroups: 1-subgroup (10 patients who received radiation therapy (RT) in combination with the inhibitor
of COX-2-ranseleks), 2- subgroup (18 patients who conducted RT). Radiation therapy is conducted using the
techniques of conformal irradiation on Clinac linear accelerator 600 c. In the first phase RT patients received an
inhibitor of COX-2-ranseleks 100 mg per day. For the determination of factors of angiogenesis VEGF, COX-2
and PGE-2 patients blood sampling carried out prior to the exposure and after radiotherapy. Level indicators were
determined in blood.
The results. Found that when using conformal radiotherapy combined with a COX-2 inhibitor positive effect was
observed in 80 % of patients with NSCLC. Partial regression prevailed whose frequency increased in patients
with NSCLC in 4.5 times. However, local radiation reactions do not exceed 2nd class, hematological toxicity-1st
degree. Found raising the content of VEGF in serum of 89 % of NSCLC, in 92.8 % of COX-2 and PGE-2 before
treatment, indicating the activation of the angiogenesis processes. The dependence of the expression of VEGF,
COX-2 and PGE-2 from stage of the disease and lesions of lymph node in patients with NSCLC. Found that levels
of COX-2 and PGE-2 remain high after RT, indicating their resistance to irradiation in patients with NSCLC. It has
been proven that influenced by the combined action of RT and inhibitor of COX-2-ranseleks reduces the content
of VEGF, COX-2 and PGE 2 in serum of patients with NSCLC.
Conclusions. Dynamic changes in VEGF, COX-2 and PGE 2 in serum of patients with NSCLC, with the combined
action of RT and inhibitor of COX-2-ranseleks were defined. It is shown that the combined action of RT and
inhibitor of COX-2 reduces the level of VEGF, COX-2 and PGE 2 in serum of patients with NSCLC that points to
a slowing of tumor angiogenesis.
Keywords: radiation therapy (RT), inhibitor of COX-2, vascular endothelial growth factor (VEGF), angiogenesis,
cyclooxygenase-2 (COX-2), prostaglandin E-2 (PGE-2), non-small-cell lung cancer (NSCLC).
2019, VOL. XXVII, PUB. 1, PAGE 20
S. BALAKA, H. HRECHIKHIN, M. KRASNOSELSKYI, A. PANOV, V. SUKHIN, M. VERBITSKYI, E. SUKHODOLSKAYA, D. VEREMEY
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
INTERVENTIONAL RADIOLOGY IN THE TREATMENT OF IATROGENIC URETERAL INJURY
Two clinical cases of minimally invasive treatment of patients with iatrogenic injury of the ureter and the formation
of ureterovaginal fistulas have been described. The development of this complication in most cases requires an open
surgical procedure, however, adhesions, inflammatory changes make it difficult to perform reconstructive surgery.
The use of interventional radiology methods, such as ureteral stenting, makes possible to close an established
fistula with minimal invasiveness and restore the integrity of the organ. At the same time, the destruction of ureter wall and the presence of urine leak greatly complicates the passage of the damage zone both antegrade through
nephrostomy access, and retrograde using cystoscopy. We have used the «rendezvous technique», the combined
use of nephrostomy and cystoscopic approaches, that allows ureteral stenting in such difficult situations
Keywords: iatrogenic ureteral injury, interventional radiology, ureteral stenting, «Rendezvous» technique.
2019, VOL. XXVII, PUB. 1, PAGE 25
A. SVYNARENKO, V. STARENKIY, O. SUKHINA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
HDR-BRACHITERAPY OF PROSTATE CANCER: CURRENT STATUS AND POSSIBILITY OF APPLICATION IN UKRAINE
A review of the use of high-dose brachytherapy in the early stages of prostate cancer is presented, the indications
for use and phasing in the complex treatment of this disease are evaluated.
Keywords: prostate cancer, HDR-brachytherapy.
2019, VOL. XXVII, PUB. 1, PAGE 31
А. TROFYMOV, L. VASYLIEV, A. SVYNARENKO
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
ROLE OF IN VIVO DOSIMETRY IN QUALITY ASSURANCE OF RADIATION THERAPY FOR PROSTATE CANCER
Objective. Assess in vivo dosimetry capabilities for monitoring the quality of external beam radiation therapy
for prostate cancer and conduct a comparative analysis of calculated and actual doses to organs at risk using
semiconductor detectors located on the anterior wall of the rectum and the posterior wall of the bladder.
Materials and methods. The study involved 63 patients with prostate cancer T1–T3a stage, without distant
metastases. Radiation therapy was carried out in a total dose of 74 Gy, 34 fractions, 5 days a week using a static
four-field method. In vivo dosimetry was performed once a week using semiconductor dosimeters located on the
anterior wall of the rectum and the posterior wall of the bladder.
Results. The calculated and actual dose data on the posterior wall of the bladder and the anterior wall of the
rectum (which are the main critical organs in radiation therapy of this localization) was compared.The average
deviation of the measured dose from the calculated one by planning system on the posterior wall of the bladder was
1.17 % ± 0.17 %, on the anterior wall of the rectum — 0.99 % ± 0.18 %.
Conclusions. The measurement results obtained in this work show the accuracy of in vivo dosimetry (using
semiconductor dosimeters) and allow the secondary verification of plans in radiation therapy to be made. These
type of dosimetry is able to measure the dose inside the patient’s body in close proximity to the irradiated volume
with high accuracy and can be used without significant changes in the clinical workflow.
Keywords: іn vivo dosimetry, prostate cancer, remote radiation therapy, quality control, organs at risk, the amount of
radiation.
2019, VOL. XXVII, PUB. 1, PAGE 38
О. SUKHINA, V. STARENKYI, A. SIMBIREVA, S. ARTIUKH
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
THE ROLE OF IN VIVO DOSIMETRY IN THE QUALITY CONTROL SYSTEM OF RADIATION THERAPY IN TREATMENT OF GENITAL AND HEAD AND NECK CANCERS
In vivo dosimetry, as part of the quality assurance of radiotherapy, should become a widely available method for
controlling the release of a planned dose in radiotherapy departments. These measures are aimed at minimizing
radiation toxicity while preserving the efficacy of radiation therapy as an integral part of complex and combined
treatment for genital cancer and cancer of the head and neck.
Keywords: quality assurance of radiation therapy, radiation toxicity, in vivo dosimetry.
2019, VOL. XXVII, PUB. 1, PAGE 43
І. S. GROMAKOVA, P. SOROCHAN, N. PROKHACH, I. PONOMARYOV, І. А. GROMAKOVA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
LEPTIN AND BREAST CANCER
Obesity is a risk factor for the development and accelerated progression of various malignant tumors, including
breast cancer. Adipokines play a significant role in the realization of the connection between obesity and breast
cancer. A key mediator of obesity effects on carcinogenesis is leptin, the circulating level of which is proportional
to fat mass. This review summarizes the results of studies indicating the relationship of leptin with the risk of developing and progression of breast cancer and highlights the mechanisms of procarcinogenic action of the hormone and leptin-directed therapeutic approaches.
Keywords: leptin, breast cancer.
2019, VOL. XXVII, PUB. 1, PAGE 49
N. KRASNOSELSKYI1, R. PODLESNIY1, A. BELIY1, 2, E. KRUTKO1
1 SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
2 Kharkiv National Medical University
PECULIARITIES OF DIAGNOSTICS AND TREATMENT OF THE METACHRONIC MALIGNANT TUMOR TUMOR PROCESS OF THE NECK AND LUNG
The article presents a description of the case of a primary multiple malignant process in a patient H., 40 years
old. The patient has been observed in the clinic of the Institute of Medical and Medical Research of the National
Academy of Medical Sciences of Ukraine since 2008 for cervical cancer (squamous cell carcinoma), and a
combined treatment has been performed. The relapse-free period for cervical cancer was 10 years. For the first
time a tumor of the upper lobe of the right lung was detected in 2013 (up to 2 cm in diameter). Within 6 years,
the patient was not examined and was not treated. I went to the clinic in February 2019 and, a CT scan revealed a
tumor of the upper lobe of the right lung of the Pankost-Tobias type.
Keywords: metachronous malignant process, lung cancer, cervical cancer, treatment.
2019, VOL. XXVII, PUB. 1, PAGE 53
Р. SOROCHAN, I. A. GROMAKOVA, N. PROKHACH, I. S. GROMAKOVA
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
HEART RATE VARIABILITY IN OBESE ENDOMETRIAL CANCER PATIENTS
Purpose of the study. To reveal peculiarities of autonomic regulation, determined by heart rate variability (HRV)
indices, in endometrial cancer patients with
different degrees of obesity.
Materials and methods. The study enrolled 63 patients with stages I–II endometrial cancer (EC) (T1а-bN0M0–
T2a-bN0M0) who had undergone total hysterectomy.
The study of HRV was performed using the Spectrum + diagnostic complex. HRV was analyzed by means of
methods of temporal and spectral analysis and the variation pulsometry method. Indicators of HRV were analyzed
in groups of patients who differed by body mass index.
Results. In patients with obesity, a decrease in HRV was recorded. The total signal power of vegetative influences
in the group with normal weight was 1561 ms2. In groups with I, II and III degrees of obesity, this indicator was
1202 ms2, 998 ms2 and 432 ms2, respectively. The lowest rates of temporal and spectral analysis of HRV were
recorded in patients with degreе III obesity. These patients also had a high stress index of regulatory systems.
Correlations between body mass index and HRV indices have been established.
Conclusions. In endometrial cancer patients with obesity, a decrease in HRV was observed, which indicates the
prevalence of sympathetic influences in these patients. The degree of disturbance of vegetative influences is directly
dependent on the degree of obesity. Lifestyle changes aimed at normalizing body weight can be recommended to
prevent disturbances of autonomic regulation and reduce the risk of endometrial cancer.
Keywords: endometrial cancer, obesity, heart rate variability.
2019, VOL. XXVII, PUB. 1, PAGE 65
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